Prolonged administration of systemic antibiotics is usual in chronic osteomyelitis
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چکیده
treatment (1). But, local implantable delivery with sustained antibiotic release may offer considerable advantages over the traditional method of therapy by producing an effective local antibiotic concentration at the diseased site, with the limitation of systemic exposure to antibiotics maintaining low systemic side effects (2). Hydroxyapatite (HAp, [Ca10(PO4)6(OH)2]) is one of the widely used bioceramics in various biomedical applications, mainly in orthopedics and dentistry, due to its close similarity to inorganic mineral components of bones and teeth (3). Because of its biocom-
منابع مشابه
The Effectiveness of Local Antibiotics in Treating Chronic Osteomyelitis in a Cohort of 50 Patients with an Average of 4 Years Follow-Up
The treatment of chronic osteomyelitis requires both appropriate surgical and antibiotic management. Prolonged intravenous antibiotic therapy followed by oral therapy is widely utilised. Despite this, the long-term recurrence rate can be up to 30%. A cohort of 50 patients from a 7-year period, 2003 to 2010, with chronic osteomyelitis was identified. This cohort was treated by surgical marginal ...
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Markedly elevated111 In labeled leukocyte activity suggestive of acute osteomyelitis was observed in a region of a composite mandibular allograft that was photon deficient on 99mTc MDP bone scintigraphy. This finding was later confirmed by surgical pathology. The patient was treated with intravenous antibiotics and returned two months later with persistent bone infection. The foHow-up thr...
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The standard recommendation for treating chronic osteomyelitis is 6 weeks of parenteral antibiotic therapy. However, oral antibiotics are available that achieve adequate levels in bone, and there are now more published studies of oral than parenteral antibiotic therapy for patients with chronic osteomyelitis. Oral and parenteral therapies achieve similar cure rates; however, oral therapy avoids...
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Up to now, orthopaedic management of chronic osteomyelitis is still problematic. Debridement and antibiotic administration is still a widely practiced management. However, oral or parenteral antibiotics often cannot reach the infection site well. Some experts have developed a system to administer local antibiotic in the form of antibiotic beads. Antibiotic beads on the market are still very exp...
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